Assay Detail
Functional
CHEMBL1041857
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at androgen receptor LBD T877A mutant in mouse NIH3T3 cells transiently transfected with beta-galactosidase reporter gene assessed as cellular transformation by R-SAT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.63 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3084681 | — | — | 1 | 9.40 |
| CHEMBL27769 | STANOLONE | 2.0 | 1 | 8.90 |
| CHEMBL3084692 | — | — | 1 | 8.10 |
| CHEMBL3084685 | — | — | 1 | 7.90 |
| CHEMBL3084686 | — | — | 1 | 7.40 |
| CHEMBL491 | HYDROXYFLUTAMIDE | 2.0 | 1 | 7.00 |
| CHEMBL806 | FLUTAMIDE | 4.0 | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3084681 | — | EC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL27769 | STANOLONE | EC50 | = | 1.259 | nM | 8.90 |
| CHEMBL3084692 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL3084685 | — | EC50 | = | 12.59 | nM | 7.90 |
| CHEMBL3084686 | — | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL491 | HYDROXYFLUTAMIDE | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL806 | FLUTAMIDE | EC50 | = | 19952.62 | nM | 4.70 |