Assay Detail
Binding
CHEMBL1042353
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Inhibition of para-aminophenylmercuric acetate-activated human pro-MMP8 after 4 hrs by fluorimetry
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.32 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179288 | — | — | 1 | 8.80 |
| CHEMBL573715 | — | — | 1 | 8.29 |
| CHEMBL572780 | — | — | 1 | 7.27 |
| CHEMBL573934 | — | — | 1 | 7.06 |
| CHEMBL573936 | — | — | 1 | 7.00 |
| CHEMBL584365 | — | — | 1 | 6.92 |
| CHEMBL573714 | — | — | 1 | 6.55 |
| CHEMBL573935 | — | — | 1 | 6.54 |
| CHEMBL584147 | — | — | 1 | 6.54 |
| CHEMBL574370 | — | — | 1 | 6.43 |
| CHEMBL574605 | — | — | 1 | 6.41 |
| CHEMBL575896 | — | — | 1 | 6.21 |
| CHEMBL574589 | — | — | 1 | 6.00 |
| CHEMBL579067 | — | — | 1 | 5.92 |
| CHEMBL584122 | — | — | 1 | 5.72 |
| CHEMBL579068 | — | — | 1 | 5.72 |
| CHEMBL575881 | — | — | 1 | 5.70 |
| CHEMBL576762 | — | — | 1 | 5.04 |
| CHEMBL575895 | — | — | 1 | 4.14 |
| CHEMBL585376 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179288 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL573715 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL572780 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL573934 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL573936 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL584365 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL573714 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL573935 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL584147 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL574370 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL574605 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL575896 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL574589 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL579067 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL584122 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL579068 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL575881 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL576762 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL575895 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL585376 | — | IC50 | = | 74000.0 | nM | 4.13 |