Assay Detail
Binding
CHEMBL1042362
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of autoactivated human pro-MMP12 after 30 mins preincubation by fluorimetry
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.91 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573715 | — | — | 1 | 9.05 |
| CHEMBL573936 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573715 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL573936 | — | IC50 | = | 170.0 | nM | 6.77 |