Assay Detail
Binding
CHEMBL1042376
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by patch-clamp assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.26 | 4.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1136 | TELITHROMYCIN | 4.0 | 1 | 4.40 |
| CHEMBL583093 | — | — | 1 | 4.37 |
| CHEMBL583299 | — | — | 1 | 4.17 |
| CHEMBL583091 | — | — | 1 | 4.10 |
| CHEMBL583090 | — | — | 1 | - |
| CHEMBL583298 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1136 | TELITHROMYCIN | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL583093 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL583299 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL583091 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL583090 | — | IC50 | = | 196000.0 | nM | - |
| CHEMBL583298 | — | IC50 | = | 140000.0 | nM | - |