Assay Detail
Functional
CHEMBL1042420
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity against Sprague-Dawley rat whole blood assessed as suppression of LPS-induced TNFalpha production by ELISA
19
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel phthalazinone derivatives as topically active phosphodiesterase 4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.96 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL594109 | — | — | 1 | 9.30 |
| CHEMBL594108 | — | — | 1 | 9.15 |
| CHEMBL596447 | — | — | 1 | 9.05 |
| CHEMBL593877 | — | — | 2 | 9.05 |
| CHEMBL592931 | — | — | 1 | 9.00 |
| CHEMBL595064 | — | — | 1 | 8.52 |
| CHEMBL596394 | — | — | 1 | 8.52 |
| CHEMBL593656 | — | — | 1 | 8.38 |
| CHEMBL595272 | — | — | 1 | 8.34 |
| CHEMBL595959 | — | — | 1 | 8.04 |
| CHEMBL595038 | — | — | 1 | 7.84 |
| CHEMBL595039 | — | — | 1 | 7.46 |
| CHEMBL605096 | — | — | 1 | 7.35 |
| CHEMBL603626 | — | — | 1 | 7.24 |
| CHEMBL605935 | — | — | 1 | 6.95 |
| CHEMBL603194 | — | — | 1 | 6.92 |
| CHEMBL440878 | — | — | 1 | 6.68 |
| CHEMBL592942 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL594109 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL594108 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL596447 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL593877 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL592931 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL595064 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL596394 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL593656 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL595272 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL595959 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL595038 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL595039 | — | IC50 | = | 34.9 | nM | 7.46 |
| CHEMBL605096 | — | IC50 | = | 44.8 | nM | 7.35 |
| CHEMBL603626 | — | IC50 | = | 57.1 | nM | 7.24 |
| CHEMBL593877 | — | IC50 | = | 82.2 | nM | 7.08 |
| CHEMBL605935 | — | IC50 | = | 112.5 | nM | 6.95 |
| CHEMBL603194 | — | IC50 | = | 118.8 | nM | 6.92 |
| CHEMBL440878 | — | IC50 | = | 207.3 | nM | 6.68 |
| CHEMBL592942 | — | IC50 | = | 442.4 | nM | 6.35 |