Assay Detail
Functional
CHEMBL1042593
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Cytotoxicity against human HCT8 cells after 72 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3-arylamino and 3-alkoxy-nor-beta-lapachone derivatives: synthesis and cytotoxicity against cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.91 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.22 |
| CHEMBL582830 | — | — | 1 | 6.82 |
| CHEMBL516585 | — | — | 1 | 6.12 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 6.08 |
| CHEMBL576075 | — | — | 1 | 5.97 |
| CHEMBL478110 | — | — | 1 | 5.95 |
| CHEMBL571623 | — | — | 1 | 5.88 |
| CHEMBL394882 | NOR-BETA-LAPACHONE | — | 1 | 5.87 |
| CHEMBL514389 | — | — | 1 | 5.83 |
| CHEMBL584338 | — | — | 1 | 5.81 |
| CHEMBL572083 | — | — | 1 | 5.80 |
| CHEMBL571407 | — | — | 1 | 5.80 |
| CHEMBL479011 | — | — | 1 | 5.76 |
| CHEMBL570552 | — | — | 1 | 5.70 |
| CHEMBL576322 | — | — | 1 | 5.58 |
| CHEMBL584746 | — | — | 1 | 5.47 |
| CHEMBL577771 | — | — | 1 | 5.36 |
| CHEMBL478526 | — | — | 1 | 5.32 |
| CHEMBL570553 | — | — | 1 | - |
| CHEMBL572084 | — | — | 1 | - |
| CHEMBL572101 | — | — | 1 | - |
| CHEMBL572318 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL582830 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL516585 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL15192 | LAPACHONE | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL576075 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL478110 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL571623 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL394882 | NOR-BETA-LAPACHONE | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL514389 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL584338 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL572083 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL571407 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL479011 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL570552 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL576322 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL584746 | — | IC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL577771 | — | IC50 | = | 4390.0 | nM | 5.36 |
| CHEMBL478526 | — | IC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL570553 | — | IC50 | > | 22000.0 | nM | - |
| CHEMBL572084 | — | IC50 | > | 13210.0 | nM | - |
| CHEMBL572101 | — | IC50 | > | 20720.0 | nM | - |
| CHEMBL572318 | — | IC50 | > | 26710.0 | nM | - |