Assay Detail
Binding
CHEMBL1042962
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of human glucokinase expressed in Escherichia coli BL21(DE3) by G6PDH-coupled spectrometry
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.82 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL608393 | — | — | 1 | 7.17 |
| CHEMBL391800 | — | — | 1 | 5.87 |
| CHEMBL239692 | — | — | 1 | 5.73 |
| CHEMBL239481 | — | — | 1 | 5.67 |
| CHEMBL394757 | — | — | 1 | 5.60 |
| CHEMBL394709 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL608393 | — | EC50 | = | 67.11 | nM | 7.17 |
| CHEMBL391800 | — | EC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL239692 | — | EC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL239481 | — | EC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL394757 | — | EC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL394709 | — | EC50 | = | 12560.0 | nM | 4.90 |