Assay Detail
Binding
CHEMBL1042997
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Inhibition of indoleamine 2,3-dioxygenase in IFN-gamma-stimulated human HeLa cells assessed as kynurenine formation by spectrophotometry
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.68 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL565923 | — | — | 1 | 7.92 |
| CHEMBL565488 | — | — | 1 | 7.77 |
| CHEMBL579014 | — | — | 1 | 7.72 |
| CHEMBL584991 | — | — | 1 | 7.72 |
| CHEMBL573690 | — | — | 1 | 7.27 |
| CHEMBL565489 | — | — | 1 | 6.92 |
| CHEMBL574139 | — | — | 1 | 6.65 |
| CHEMBL567225 | — | — | 1 | 6.57 |
| CHEMBL577494 | — | — | 1 | 6.31 |
| CHEMBL568287 | — | — | 1 | 6.01 |
| CHEMBL585186 | — | — | 1 | 6.00 |
| CHEMBL576019 | — | — | 1 | 5.82 |
| CHEMBL573686 | — | — | 1 | 5.62 |
| CHEMBL577067 | — | — | 1 | 5.17 |
| CHEMBL565924 | — | — | 1 | - |
| CHEMBL584992 | — | — | 1 | - |
| CHEMBL567441 | — | — | 1 | - |
| CHEMBL567442 | — | — | 1 | - |
| CHEMBL567317 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL565923 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL565488 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL579014 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL584991 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL573690 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL565489 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL574139 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL567225 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL577494 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL568287 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL585186 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL576019 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL573686 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL577067 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL565924 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL584992 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL567441 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL567442 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL567317 | — | IC50 | > | 2000.0 | nM | - |