Assay Detail
Binding
CHEMBL1043196
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Inhibition of wild type HIV reverse transcriptase in presence of poly(rA) template, (dT) 12-18 primer
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Pyrazole NNRTIs 1: design and initial optimisation of a novel template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.99 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575794 | — | — | 1 | 9.92 |
| CHEMBL435128 | CAPRAVIRINE | 2.0 | 1 | 9.46 |
| CHEMBL584979 | — | — | 1 | 9.40 |
| CHEMBL575314 | — | — | 1 | 8.89 |
| CHEMBL577826 | — | — | 1 | 8.52 |
| CHEMBL584809 | — | — | 1 | 7.72 |
| CHEMBL576564 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575794 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL435128 | CAPRAVIRINE | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL584979 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL575314 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL577826 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL584809 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL576564 | — | IC50 | - | — | - |