Assay Detail
Binding
CHEMBL1043448
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Inhibition of CDK2
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.89 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL576257 | — | — | 1 | 7.52 |
| CHEMBL570002 | — | — | 1 | 7.30 |
| CHEMBL569720 | — | — | 1 | 6.39 |
| CHEMBL578201 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL576257 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL570002 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL569720 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL578201 | — | IC50 | = | 460.0 | nM | 6.34 |