Assay Detail
Binding
CHEMBL1043646
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [35S]-labeled ligand from VLA4 in human Jurkat cells washed with buffer containing non activating Ca2+ and Mg2+ by competitive binding assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 9.82 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL569442 | — | — | 1 | 10.70 |
| CHEMBL566154 | — | — | 1 | 10.52 |
| CHEMBL569443 | — | — | 1 | 10.00 |
| CHEMBL569263 | — | — | 1 | 9.96 |
| CHEMBL569276 | — | — | 1 | 9.92 |
| CHEMBL506044 | — | — | 1 | 9.82 |
| CHEMBL569403 | — | — | 1 | 9.82 |
| CHEMBL567433 | — | — | 1 | 9.68 |
| CHEMBL569255 | — | — | 1 | 9.66 |
| CHEMBL569444 | — | — | 1 | 9.66 |
| CHEMBL569302 | — | — | 1 | 9.62 |
| CHEMBL571805 | — | — | 1 | 9.57 |
| CHEMBL565499 | — | — | 1 | 9.46 |
| CHEMBL569407 | — | — | 1 | 9.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL569442 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL566154 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL569443 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL569263 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL569276 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL506044 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL569403 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL567433 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL569255 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL569444 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL569302 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL571805 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL565499 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL569407 | — | IC50 | = | 0.9 | nM | 9.05 |