Assay Detail
Binding
CHEMBL1043697
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Inhibition of ADAM9
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Disintegrin and metalloproteinase domain-containing protein 9 (CHEMBL5982) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.73 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296588 | PEPSTATIN | 2.0 | 1 | 7.25 |
| CHEMBL19611 | ILOMASTAT | 2.0 | 1 | 7.25 |
| CHEMBL567893 | GRASSYSTATIN A | — | 1 | 4.34 |
| CHEMBL568553 | GRASSYSTATIN B | — | 1 | 4.07 |
| CHEMBL569445 | GRASSYSTATIN C | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296588 | PEPSTATIN | IC50 | = | 56.3 | nM | 7.25 |
| CHEMBL19611 | ILOMASTAT | IC50 | = | 56.3 | nM | 7.25 |
| CHEMBL567893 | GRASSYSTATIN A | IC50 | = | 46100.0 | nM | 4.34 |
| CHEMBL568553 | GRASSYSTATIN B | IC50 | = | 85500.0 | nM | 4.07 |
| CHEMBL569445 | GRASSYSTATIN C | IC50 | > | 100000.0 | nM | - |