Assay Detail
Binding
CHEMBL1044030
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant SIRT1 after 60 mins by fluorimetric analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
NAD-dependent protein deacetylase sirtuin-1 (CHEMBL4506) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.79 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL584353 | — | — | 1 | 5.57 |
| CHEMBL1140 | NIACINAMIDE | 4.0 | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL584353 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1140 | NIACINAMIDE | IC50 | = | 100000.0 | nM | 4.00 |