Assay Detail
Binding
CHEMBL1044082
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Inhibition of human NET expressed in MDCK-Net6 cells
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDCK-Net6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of the 1-amino-3-(1H-indol-1-yl)-3-phenylpropan-2-ol series of monoamine reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.43 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72 | DESIPRAMINE | 4.0 | 1 | 8.47 |
| CHEMBL576145 | — | — | 1 | 8.40 |
| CHEMBL575132 | — | — | 1 | 8.15 |
| CHEMBL576758 | — | — | 1 | 8.00 |
| CHEMBL576170 | — | — | 1 | 7.96 |
| CHEMBL574920 | — | — | 1 | 7.85 |
| CHEMBL574921 | — | — | 1 | 7.82 |
| CHEMBL575535 | — | — | 1 | 7.80 |
| CHEMBL566090 | — | — | 1 | 7.80 |
| CHEMBL583411 | — | — | 1 | 7.75 |
| CHEMBL575546 | — | — | 1 | 7.70 |
| CHEMBL572927 | — | — | 1 | 7.68 |
| CHEMBL579244 | — | — | 1 | 7.68 |
| CHEMBL572951 | — | — | 1 | 7.68 |
| CHEMBL577597 | — | — | 1 | 7.66 |
| CHEMBL562476 | — | — | 1 | 7.55 |
| CHEMBL573667 | — | — | 1 | 7.47 |
| CHEMBL577825 | — | — | 1 | 7.31 |
| CHEMBL575133 | — | — | 1 | 7.28 |
| CHEMBL577138 | — | — | 1 | 7.27 |
| CHEMBL566958 | — | — | 1 | 7.22 |
| CHEMBL572917 | — | — | 1 | 7.22 |
| CHEMBL584152 | — | — | 1 | 7.19 |
| CHEMBL575131 | — | — | 1 | 7.08 |
| CHEMBL575753 | — | — | 1 | 7.04 |
| CHEMBL577598 | — | — | 1 | 7.04 |
| CHEMBL576542 | — | — | 1 | 7.04 |
| CHEMBL582894 | — | — | 1 | 6.96 |
| CHEMBL566957 | — | — | 1 | 6.93 |
| CHEMBL577565 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72 | DESIPRAMINE | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL576145 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL575132 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL576758 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL576170 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL574920 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL574921 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL575535 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL566090 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL583411 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL575546 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL572927 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL579244 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL572951 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL577597 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL562476 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL573667 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL577825 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL575133 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL577138 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL566958 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL572917 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL584152 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL575131 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL575753 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL577598 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL576542 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL582894 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL566957 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL577565 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL578841 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL583113 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL577612 | — | IC50 | = | 527.0 | nM | 6.28 |