Assay Detail
Functional
CHEMBL1044096
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Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT K2 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Enhancement of the antimalarial activity of ciprofloxacin using a double prodrug/bioorganometallic approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.42 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.74 |
| CHEMBL170 | QUININE | 4.0 | 1 | 8.17 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.28 |
| CHEMBL1200699 | DOXYCYCLINE | 4.0 | 1 | 4.83 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL170 | QUININE | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 523.0 | nM | 6.28 |
| CHEMBL1200699 | DOXYCYCLINE | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 80800.0 | nM | 4.09 |