Assay Detail
Binding
CHEMBL1044345
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CP-55940 from recombinant human CB1 receptor expressed in CHO cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-aminopropanamide as human cannabinoid-1 receptor (CB1R) inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.44 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220360 | TARANABANT | 3.0 | 1 | 9.52 |
| CHEMBL567679 | — | — | 1 | 8.80 |
| CHEMBL582806 | — | — | 1 | 8.12 |
| CHEMBL582820 | — | — | 1 | 8.07 |
| CHEMBL572097 | — | — | 1 | 8.00 |
| CHEMBL569292 | — | — | 1 | 7.91 |
| CHEMBL567874 | — | — | 1 | 7.75 |
| CHEMBL572271 | — | — | 1 | 7.71 |
| CHEMBL567876 | — | — | 1 | 7.42 |
| CHEMBL568849 | — | — | 1 | 7.34 |
| CHEMBL584309 | — | — | 1 | 7.32 |
| CHEMBL567461 | — | — | 1 | 7.31 |
| CHEMBL568094 | — | — | 1 | 7.31 |
| CHEMBL567513 | — | — | 1 | 7.01 |
| CHEMBL571204 | — | — | 1 | 6.88 |
| CHEMBL572080 | — | — | 1 | 6.87 |
| CHEMBL571831 | — | — | 1 | 6.73 |
| CHEMBL567297 | — | — | 1 | 6.69 |
| CHEMBL584332 | — | — | 1 | 6.52 |
| CHEMBL569614 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220360 | TARANABANT | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL567679 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL582806 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL582820 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL572097 | — | IC50 | = | 10.1 | nM | 8.00 |
| CHEMBL569292 | — | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL567874 | — | IC50 | = | 17.9 | nM | 7.75 |
| CHEMBL572271 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL567876 | — | IC50 | = | 37.7 | nM | 7.42 |
| CHEMBL568849 | — | IC50 | = | 46.1 | nM | 7.34 |
| CHEMBL584309 | — | IC50 | = | 47.7 | nM | 7.32 |
| CHEMBL567461 | — | IC50 | = | 49.2 | nM | 7.31 |
| CHEMBL568094 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL567513 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL571204 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL572080 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL571831 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL567297 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL584332 | — | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL569614 | — | IC50 | = | 2982.0 | nM | 5.53 |