Assay Detail
Binding
CHEMBL1044683
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Inhibition of human PDE4
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 9.21 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1204130 | — | — | 1 | 9.70 |
| CHEMBL571060 | — | — | 1 | 9.70 |
| CHEMBL1204131 | — | — | 1 | 9.70 |
| CHEMBL570939 | — | — | 1 | 9.70 |
| CHEMBL568232 | — | — | 1 | 9.52 |
| CHEMBL1204128 | — | — | 1 | 9.40 |
| CHEMBL1204129 | — | — | 1 | 9.40 |
| CHEMBL571029 | — | — | 1 | 9.40 |
| CHEMBL585566 | — | — | 1 | 9.22 |
| CHEMBL591662 | — | — | 1 | 9.15 |
| CHEMBL584475 | — | — | 1 | 9.10 |
| CHEMBL571022 | — | — | 1 | 9.05 |
| CHEMBL578359 | — | — | 1 | 9.05 |
| CHEMBL372575 | — | — | 1 | 9.00 |
| CHEMBL568446 | — | — | 1 | 8.89 |
| CHEMBL579266 | — | — | 1 | 8.85 |
| CHEMBL586818 | — | — | 1 | 8.85 |
| CHEMBL570839 | — | — | 1 | 8.85 |
| CHEMBL567585 | — | — | 1 | 8.82 |
| CHEMBL565558 | — | — | 1 | 8.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1204130 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL571060 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1204131 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL570939 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL568232 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1204128 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1204129 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL571029 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL585566 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL591662 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL584475 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL571022 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL578359 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL372575 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL568446 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL579266 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL586818 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL570839 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL567585 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL565558 | — | IC50 | = | 1.7 | nM | 8.77 |