Assay Detail
Binding
CHEMBL1044713
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Inhibition of GST-fused CDK5/p25 expressed in Escherichia coli assessed as [gamma-33P]ATP incorporation after 10 mins by scintillation counting
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and kinase inhibitory activity of novel substituted indigoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.53 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL369303 | — | — | 1 | 8.22 |
| CHEMBL593698 | — | — | 1 | 7.75 |
| CHEMBL1086983 | — | — | 1 | 7.30 |
| CHEMBL604270 | — | — | 1 | 6.96 |
| CHEMBL594403 | — | — | 1 | 6.92 |
| CHEMBL604263 | — | — | 1 | 6.82 |
| CHEMBL445348 | — | — | 1 | 6.80 |
| CHEMBL593968 | — | — | 1 | 6.70 |
| CHEMBL606982 | — | — | 1 | 6.52 |
| CHEMBL610451 | — | — | 1 | 6.26 |
| CHEMBL594192 | — | — | 1 | 6.23 |
| CHEMBL606920 | — | — | 1 | 6.00 |
| CHEMBL594857 | — | — | 1 | 5.48 |
| CHEMBL609580 | — | — | 1 | 5.40 |
| CHEMBL174025 | — | — | 1 | 4.60 |
| CHEMBL605926 | — | — | 1 | - |
| CHEMBL606814 | — | — | 1 | - |
| CHEMBL603641 | — | — | 1 | - |
| CHEMBL596037 | — | — | 1 | - |
| CHEMBL604470 | — | — | 1 | - |
| CHEMBL593700 | — | — | 1 | - |
| CHEMBL606865 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL369303 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL593698 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1086983 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL604270 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL594403 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL604263 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL445348 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL593968 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL606982 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL610451 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL594192 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL606920 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL594857 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL609580 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL174025 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL605926 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL606814 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL603641 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL596037 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL604470 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL593700 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL606865 | — | IC50 | > | 10000.0 | nM | - |