Assay Detail
Functional
CHEMBL1044718
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Antiproliferative activity against human Caco-2 cells after 72 hrs by imaging analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Caco-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and kinase inhibitory activity of novel substituted indigoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.79 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.70 |
| CHEMBL594192 | — | — | 1 | 5.70 |
| CHEMBL593700 | — | — | 1 | 5.52 |
| CHEMBL593698 | — | — | 1 | 5.30 |
| CHEMBL609580 | — | — | 1 | 5.30 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 5.22 |
| CHEMBL603200 | — | — | 1 | - |
| CHEMBL594189 | (3'Z)-5-AMINOISOINDIGO | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL594192 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL593700 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL593698 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL609580 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL603200 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL594189 | (3'Z)-5-AMINOISOINDIGO | IC50 | > | 25000.0 | nM | - |