Assay Detail
Binding
CHEMBL1044822
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Inhibition of human DHFR assessed as rate of NADPH consumption using dihydrofolate as substrate
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
In vitro biological activity and structural analysis of 2,4-diamino-5-(2'-arylpropargyl)pyrimidine inhibitors of Candida albicans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.99 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485959 | — | — | 1 | 7.24 |
| CHEMBL584390 | — | — | 1 | 7.22 |
| CHEMBL575223 | — | — | 1 | 7.06 |
| CHEMBL572485 | — | — | 1 | 6.75 |
| CHEMBL574335 | — | — | 1 | 6.70 |
| CHEMBL578424 | — | — | 1 | 6.68 |
| CHEMBL582843 | — | — | 1 | 6.54 |
| CHEMBL574329 | — | — | 1 | 6.40 |
| CHEMBL220159 | — | — | 1 | 6.40 |
| CHEMBL575217 | — | — | 1 | 6.12 |
| CHEMBL220936 | — | — | 1 | 5.94 |
| CHEMBL485962 | — | — | 1 | 5.93 |
| CHEMBL573880 | — | — | 1 | 5.92 |
| CHEMBL220937 | — | — | 1 | 5.91 |
| CHEMBL457725 | — | — | 1 | 5.90 |
| CHEMBL485960 | — | — | 1 | 5.89 |
| CHEMBL485961 | — | — | 1 | 5.89 |
| CHEMBL485569 | — | — | 1 | 5.87 |
| CHEMBL459177 | — | — | 1 | 5.87 |
| CHEMBL222461 | — | — | 1 | 5.86 |
| CHEMBL459178 | — | — | 1 | 5.86 |
| CHEMBL457905 | — | — | 1 | 5.85 |
| CHEMBL584391 | — | — | 1 | 5.85 |
| CHEMBL219889 | — | — | 1 | 5.84 |
| CHEMBL219624 | — | — | 1 | 5.84 |
| CHEMBL572717 | — | — | 1 | 5.80 |
| CHEMBL520358 | — | — | 1 | 5.77 |
| CHEMBL574559 | — | — | 1 | 5.64 |
| CHEMBL457906 | — | — | 1 | 5.56 |
| CHEMBL521055 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485959 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL584390 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL575223 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL572485 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL574335 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL578424 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL582843 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL574329 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL220159 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL575217 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL220936 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL485962 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL573880 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL220937 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL457725 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL485960 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL485961 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL459177 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL485569 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL222461 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL459178 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL457905 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL584391 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL219889 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL219624 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL572717 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL520358 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL574559 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL457906 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL521055 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL458817 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL458829 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL221172 | — | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL457726 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL384443 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 198000.0 | nM | - |