Assay Detail
Binding
CHEMBL1044832
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Inhibition of stearoyl-CoA delta9 desaturase in human HepG2 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.11 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494748 | — | — | 1 | 10.30 |
| CHEMBL572876 | — | — | 1 | 9.30 |
| CHEMBL575817 | — | — | 1 | 8.57 |
| CHEMBL573829 | — | — | 1 | 8.21 |
| CHEMBL493960 | — | — | 1 | 8.07 |
| CHEMBL493961 | — | — | 1 | 7.48 |
| CHEMBL577141 | — | — | 1 | 7.17 |
| CHEMBL466674 | — | — | 1 | 6.96 |
| CHEMBL444433 | — | — | 1 | 6.92 |
| CHEMBL576780 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494748 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL572876 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL575817 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL573829 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL493960 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL493961 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL577141 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL466674 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL444433 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL576780 | — | IC50 | > | 1000.0 | nM | - |