Assay Detail
Functional
CHEMBL1045079
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Antiproliferative activity against human PC3 cells after 72 hrs by trypan blue exclusion assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.12 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL392591 | — | — | 1 | 6.85 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.85 |
| CHEMBL392384 | — | — | 1 | 6.25 |
| CHEMBL611361 | — | — | 1 | 6.08 |
| CHEMBL239211 | — | — | 1 | 6.03 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 5.95 |
| CHEMBL611052 | — | — | 1 | 5.80 |
| CHEMBL15193 | LAPACHOL | — | 1 | 5.71 |
| CHEMBL493650 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL392591 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL105 | MITOMYCIN | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL392384 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL611361 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL239211 | — | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL15192 | LAPACHONE | EC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL611052 | — | EC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL15193 | LAPACHOL | EC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL493650 | — | EC50 | = | 3000.0 | nM | 5.52 |