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Assay Detail

CHEMBL1045092

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells after 48 hrs by immunofluorescence technique
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human gammaherpesvirus 4
Cell Type Raji
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae.
Yamashita M, Kaneko M, Tokuda H, Nishimura K, Kumeda Y, Iida A.
Bioorg Med Chem (2009) 17 : 6286 -6291
PubMed 19674905 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 4.44 4.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL392591 1 4.48
CHEMBL392384 1 4.46
CHEMBL611361 1 4.43
CHEMBL239211 1 4.41
CHEMBL493650 1 4.40
CHEMBL611052 1 -
CHEMBL596002 1 -
CHEMBL15192 LAPACHONE 2.0 1 -
CHEMBL15193 LAPACHOL 1 -
CHEMBL140 CURCUMIN 3.0 1 -
CHEMBL486599 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL392591 IC50 = 33200.0 nM 4.48
CHEMBL392384 IC50 = 34900.0 nM 4.46
CHEMBL611361 IC50 = 37200.0 nM 4.43
CHEMBL239211 IC50 = 38900.0 nM 4.41
CHEMBL493650 IC50 = 40100.0 nM 4.40
CHEMBL611052 IC50 = 271000.0 nM -
CHEMBL596002 IC50 = 201100.0 nM -
CHEMBL15192 LAPACHONE IC50 = 210300.0 nM -
CHEMBL15193 LAPACHOL IC50 = 311400.0 nM -
CHEMBL140 CURCUMIN IC50 = 345000.0 nM -
CHEMBL486599 IC50 = 306500.0 nM -