Assay Detail
Binding
CHEMBL1045248
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Inhibition of human somatic NEP
18
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.83 | 8.85 |
| IC50 | 3 | 6.74 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL571153 | — | — | 1 | 8.85 |
| CHEMBL289556 | OMAPATRILAT | 2.0 | 1 | 8.05 |
| CHEMBL479579 | PHOSPHORAMIDON | — | 1 | 7.52 |
| CHEMBL570740 | — | — | 1 | 7.28 |
| CHEMBL570718 | — | — | 1 | 7.17 |
| CHEMBL570811 | — | — | 1 | 7.07 |
| CHEMBL43370 | — | — | 1 | 7.05 |
| CHEMBL577753 | — | — | 1 | 6.89 |
| CHEMBL570732 | — | — | 1 | 6.76 |
| CHEMBL570843 | — | — | 1 | 6.58 |
| CHEMBL577754 | — | — | 1 | 5.73 |
| CHEMBL146936 | — | — | 1 | 5.64 |
| CHEMBL570842 | — | — | 1 | 5.60 |
| CHEMBL570953 | — | — | 1 | 5.17 |
| CHEMBL570722 | — | — | 1 | - |
| CHEMBL567628 | — | — | 1 | - |
| CHEMBL570704 | — | — | 1 | - |
| CHEMBL571716 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL571153 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL289556 | OMAPATRILAT | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL479579 | PHOSPHORAMIDON | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL570740 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL570718 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL570811 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL43370 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL577753 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL570732 | — | Ki | = | 172.0 | nM | 6.76 |
| CHEMBL570843 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL577754 | — | Ki | = | 1850.0 | nM | 5.73 |
| CHEMBL146936 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL570842 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL570953 | — | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL570722 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL567628 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL570704 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL571716 | — | Ki | > | 50000.0 | nM | - |