Assay Detail
Binding
CHEMBL1045250
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Inhibition of human MMP13
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.84 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL577753 | — | — | 1 | 7.72 |
| CHEMBL570732 | — | — | 1 | 7.62 |
| CHEMBL570718 | — | — | 1 | 7.52 |
| CHEMBL577754 | — | — | 1 | 5.92 |
| CHEMBL570953 | — | — | 1 | 5.40 |
| CHEMBL567628 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL577753 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL570732 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL570718 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL577754 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL570953 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL567628 | — | Ki | > | 10000.0 | nM | - |