Assay Detail
Functional
CHEMBL1045633
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Agonist activity at human delta opioid receptor expressed in HN9.10 cells assessed as stimulation of [35S]GTPgammaS binding
12
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 8.32 | 10.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL611926 | — | — | 2 | 10.76 |
| CHEMBL200199 | BIPHALIN | — | 2 | 8.96 |
| CHEMBL507340 | — | — | 2 | 8.07 |
| CHEMBL592969 | — | — | 2 | 7.89 |
| CHEMBL611924 | — | — | 2 | 7.29 |
| CHEMBL611925 | — | — | 2 | 7.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL611926 | — | EC50 | = | 0.01738 | nM | 10.76 |
| CHEMBL611926 | — | EC50 | = | 0.02 | nM | 10.70 |
| CHEMBL200199 | BIPHALIN | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL200199 | BIPHALIN | EC50 | = | 1.122 | nM | 8.95 |
| CHEMBL507340 | — | EC50 | = | 8.511 | nM | 8.07 |
| CHEMBL507340 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL592969 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL592969 | — | EC50 | = | 13.18 | nM | 7.88 |
| CHEMBL611924 | — | EC50 | = | 51.29 | nM | 7.29 |
| CHEMBL611924 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL611925 | — | EC50 | = | 97.72 | nM | 7.01 |
| CHEMBL611925 | — | EC50 | = | 98.0 | nM | 7.01 |