Assay Detail
Functional
CHEMBL1045658
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Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.37 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385064 | — | — | 1 | 7.52 |
| CHEMBL231616 | TRIAPINE | 3.0 | 1 | 6.58 |
| CHEMBL390195 | — | — | 1 | 6.52 |
| CHEMBL505209 | — | — | 1 | 6.30 |
| CHEMBL522881 | — | — | 1 | 6.30 |
| CHEMBL567857 | — | — | 1 | 6.30 |
| CHEMBL567856 | — | — | 1 | 6.30 |
| CHEMBL565912 | — | — | 1 | 6.30 |
| CHEMBL573915 | — | — | 1 | 6.30 |
| CHEMBL568308 | — | — | 1 | 6.30 |
| CHEMBL556 | DEFEROXAMINE | 4.0 | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385064 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL231616 | TRIAPINE | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL390195 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL505209 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL522881 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL567857 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL567856 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL565912 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL573915 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL568308 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL556 | DEFEROXAMINE | IC50 | = | 5000.0 | nM | 5.30 |