Assay Detail
ADMET
CHEMBL1045883
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against hamster UV4 cells after 4 hrs under aerobic conditions
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cricetulus griseus |
| Cell Type | UV4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of stable bidentate transition metal complexes of 1-(chloromethyl)-5-hydroxy-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinoline (seco-6-azaCBI-TMI) as hypoxia selective cytotoxins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.36 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL571037 | — | — | 1 | 10.40 |
| CHEMBL583045 | — | — | 1 | 10.15 |
| CHEMBL571270 | — | — | 1 | 9.14 |
| CHEMBL569395 | — | — | 1 | 8.77 |
| CHEMBL583048 | — | — | 1 | 8.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL571037 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL583045 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL571270 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL569395 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL583048 | — | IC50 | = | 4.6 | nM | 8.34 |