Assay Detail
Functional
CHEMBL1046469
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Antiangiogenic activity against HUVECs by Brdu incorporation assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 2- and 17-substituted estrone analogs and their antiproliferative structure-activity relationships compared to 2-methoxyestradiol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.35 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL603960 | — | — | 1 | 6.72 |
| CHEMBL594117 | — | — | 1 | 6.58 |
| CHEMBL609566 | — | — | 1 | 6.15 |
| CHEMBL299613 | 2-METHOXYESTRADIOL | 2.0 | 1 | 6.08 |
| CHEMBL608104 | — | — | 1 | 5.88 |
| CHEMBL595755 | — | — | 1 | 5.62 |
| CHEMBL594474 | — | — | 1 | 5.55 |
| CHEMBL605513 | — | — | 1 | 5.49 |
| CHEMBL595756 | — | — | 1 | 5.46 |
| CHEMBL594568 | — | — | 1 | 5.44 |
| CHEMBL595647 | — | — | 1 | 5.39 |
| CHEMBL593102 | — | — | 1 | 5.37 |
| CHEMBL595878 | — | — | 1 | 5.34 |
| CHEMBL608114 | — | — | 1 | 5.17 |
| CHEMBL595667 | — | — | 1 | 5.13 |
| CHEMBL595421 | — | — | 1 | 5.10 |
| CHEMBL261406 | — | — | 1 | 5.08 |
| CHEMBL604895 | — | — | 1 | 4.90 |
| CHEMBL593789 | — | — | 1 | 4.87 |
| CHEMBL604882 | — | — | 1 | 4.73 |
| CHEMBL603320 | — | — | 1 | 4.45 |
| CHEMBL594118 | — | — | 1 | 4.39 |
| CHEMBL595896 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL603960 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL594117 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL609566 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL299613 | 2-METHOXYESTRADIOL | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL608104 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL595755 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL594474 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL605513 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL595756 | — | IC50 | = | 3470.0 | nM | 5.46 |
| CHEMBL594568 | — | IC50 | = | 3630.0 | nM | 5.44 |
| CHEMBL595647 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL593102 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL595878 | — | IC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL608114 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL595667 | — | IC50 | = | 7430.0 | nM | 5.13 |
| CHEMBL595421 | — | IC50 | = | 7950.0 | nM | 5.10 |
| CHEMBL261406 | — | IC50 | = | 8220.0 | nM | 5.08 |
| CHEMBL604895 | — | IC50 | = | 12640.0 | nM | 4.90 |
| CHEMBL593789 | — | IC50 | = | 13370.0 | nM | 4.87 |
| CHEMBL604882 | — | IC50 | = | 18810.0 | nM | 4.73 |
| CHEMBL603320 | — | IC50 | = | 35900.0 | nM | 4.45 |
| CHEMBL594118 | — | IC50 | = | 40790.0 | nM | 4.39 |
| CHEMBL595896 | — | IC50 | = | 60050.0 | nM | 4.22 |