Assay Detail
ADMET
CHEMBL1046519
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Growth inhibition of human NHDF after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | NHDF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.48 | 5.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575109 | — | — | 1 | 5.03 |
| CHEMBL481250 | ANHYDROLYCORINE | — | 1 | 4.58 |
| CHEMBL586091 | PSEUDOLYCORINE | — | 1 | 4.17 |
| CHEMBL575771 | — | — | 1 | 4.14 |
| CHEMBL400092 | LYCORINE | — | 1 | - |
| CHEMBL516707 | — | — | 1 | - |
| CHEMBL574915 | LYCORINE HYDROCHLORIDE | — | 1 | - |
| CHEMBL575533 | AMARBELLISINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575109 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL481250 | ANHYDROLYCORINE | IC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL586091 | PSEUDOLYCORINE | IC50 | = | 66900.0 | nM | 4.17 |
| CHEMBL575771 | — | IC50 | = | 72100.0 | nM | 4.14 |
| CHEMBL400092 | LYCORINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL516707 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL574915 | LYCORINE HYDROCHLORIDE | IC50 | > | 100000.0 | nM | - |
| CHEMBL575533 | AMARBELLISINE | IC50 | > | 100000.0 | nM | - |