Assay Detail
Binding
CHEMBL1046742
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]prazosin from adrenergic alpha1A receptor in Wistar rat submaxillary gland after 60 mins
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Submaxillary gland |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Further studies on arylpiperazinyl alkyl pyridazinones: discovery of an exceptionally potent, orally active, antinociceptive agent in thermally induced pain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.43 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1558 | PRAZOSIN HYDROCHLORIDE | 4.0 | 1 | 9.60 |
| CHEMBL584606 | — | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1558 | PRAZOSIN HYDROCHLORIDE | IC50 | = | 0.254 | nM | 9.60 |
| CHEMBL584606 | — | IC50 | = | 56.0 | nM | 7.25 |