Assay Detail
Binding
CHEMBL1046768
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Inhibition of EphB4 by [gamma33-P]ATP based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Structure-based optimization of potent and selective inhibitors of the tyrosine kinase erythropoietin producing human hepatocellular carcinoma receptor B4 (EphB4).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.68 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566515 | — | — | 1 | 8.80 |
| CHEMBL574236 | — | — | 1 | 7.33 |
| CHEMBL575335 | — | — | 1 | 6.67 |
| CHEMBL577156 | — | — | 1 | 5.36 |
| CHEMBL271179 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566515 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL574236 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL575335 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL577156 | — | IC50 | = | 4350.0 | nM | 5.36 |
| CHEMBL271179 | — | IC50 | = | 5680.0 | nM | 5.25 |