Assay Detail
Binding
CHEMBL1047044
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Inhibition of Mycobacterium tuberculosis H37Rv MetAP1c in presence of 50 uM Ni(2+) by Met-AMC substrate hydrolysis assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis H37Rv |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Catalysis and inhibition of Mycobacterium tuberculosis methionine aminopeptidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.71 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL569750 | — | — | 1 | 6.62 |
| CHEMBL568826 | — | — | 1 | 6.24 |
| CHEMBL569683 | — | — | 1 | 5.89 |
| CHEMBL568651 | — | — | 1 | 5.60 |
| CHEMBL475078 | — | — | 1 | 4.22 |
| CHEMBL495123 | — | — | 1 | - |
| CHEMBL370437 | — | — | 1 | - |
| CHEMBL200238 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL569750 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL568826 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL569683 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL568651 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL475078 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL495123 | — | IC50 | = | 104000.0 | nM | - |
| CHEMBL370437 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL200238 | — | IC50 | > | 500000.0 | nM | - |