Assay Detail
Binding
CHEMBL1047082
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]alpha-bungarotoxin from rat alpha7 nAChR
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design of novel alpha7-subtype-preferring nicotinic acetylcholine receptor agonists: application of docking and MM-PBSA computational approaches, synthetic and pharmacological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.78 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64779 | — | — | 1 | 6.85 |
| CHEMBL570620 | — | — | 1 | 6.46 |
| CHEMBL577107 | — | — | 1 | 6.40 |
| CHEMBL579276 | — | — | 1 | 5.25 |
| CHEMBL577968 | — | — | 1 | 5.21 |
| CHEMBL571077 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64779 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL570620 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL577107 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL579276 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL577968 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL571077 | — | Ki | = | 33000.0 | nM | 4.48 |