Assay Detail
Binding
CHEMBL1047083
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]epibatidine from rat alpha4beta2 nAChR
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor; alpha4/beta2 (CHEMBL1907596) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Design of novel alpha7-subtype-preferring nicotinic acetylcholine receptor agonists: application of docking and MM-PBSA computational approaches, synthetic and pharmacological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.22 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64779 | — | — | 1 | 6.96 |
| CHEMBL577107 | — | — | 1 | 5.51 |
| CHEMBL571077 | — | — | 1 | 4.92 |
| CHEMBL570620 | — | — | 1 | 4.68 |
| CHEMBL579276 | — | — | 1 | 4.66 |
| CHEMBL577968 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64779 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL577107 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL571077 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL570620 | — | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL579276 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL577968 | — | Ki | = | 25000.0 | nM | 4.60 |