Assay Detail
Binding
CHEMBL1047417
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Braf V600E mutant
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.97 | 9.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385956 | — | — | 1 | 9.34 |
| CHEMBL3215582 | — | — | 1 | 8.80 |
| CHEMBL212964 | — | — | 1 | 8.77 |
| CHEMBL565884 | — | — | 1 | 8.47 |
| CHEMBL576787 | — | — | 1 | 8.27 |
| CHEMBL571703 | — | — | 1 | 7.77 |
| CHEMBL571278 | — | — | 1 | 7.75 |
| CHEMBL576985 | — | — | 1 | 7.68 |
| CHEMBL570567 | — | — | 1 | 7.41 |
| CHEMBL565885 | — | — | 1 | 7.25 |
| CHEMBL569882 | — | — | 1 | 7.16 |
| CHEMBL570573 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385956 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL3215582 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL212964 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL565884 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL576787 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL571703 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL571278 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL576985 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL570567 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL565885 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL569882 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL570573 | — | IC50 | = | 110.0 | nM | 6.96 |