Assay Detail
Functional
CHEMBL1047864
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Antimalarial activity against drug-sensitive Plasmodium falciparum 3D7 assessed as [3H]hypoxanthine incorporation by scintillation counting
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antiplasmodial activity of new indolone N-oxide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.32 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567979 | — | — | 1 | 8.77 |
| CHEMBL207675 | SODIUM ARESUNATE | — | 1 | 8.40 |
| CHEMBL576596 | — | — | 1 | 7.68 |
| CHEMBL565868 | — | — | 1 | 7.57 |
| CHEMBL576595 | — | — | 1 | 7.52 |
| CHEMBL565855 | — | — | 1 | 7.50 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.46 |
| CHEMBL566909 | — | — | 1 | 7.43 |
| CHEMBL579223 | — | — | 1 | 7.24 |
| CHEMBL565854 | — | — | 1 | 7.21 |
| CHEMBL566943 | — | — | 1 | 7.16 |
| CHEMBL585890 | — | — | 1 | 7.14 |
| CHEMBL576517 | — | — | 1 | 7.09 |
| CHEMBL568179 | — | — | 1 | 7.05 |
| CHEMBL567970 | — | — | 1 | 7.01 |
| CHEMBL581422 | — | — | 1 | 7.00 |
| CHEMBL567966 | — | — | 1 | 6.86 |
| CHEMBL567557 | — | — | 1 | 6.85 |
| CHEMBL1163014 | — | — | 1 | 6.83 |
| CHEMBL567535 | — | — | 1 | 6.54 |
| CHEMBL568161 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567979 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL207675 | SODIUM ARESUNATE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL576596 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL565868 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL576595 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL565855 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL566909 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL579223 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL565854 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL566943 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL585890 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL576517 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL568179 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL567970 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL581422 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL567966 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL567557 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL1163014 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL567535 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL568161 | — | IC50 | < | 0.5 | nM | - |