Assay Detail
Functional
CHEMBL1047873
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Antimalarial activity against Plasmodium falciparum 3D7 infected in human O+ erythrocytes after 72 hrs by [3H]hypoxanthine incorporation assay using DAPI staining
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and in vitro DMPK profiling of a 1,2-dioxolane-based library with activity against Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 41 | 7.44 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL583442 | — | — | 1 | 7.80 |
| CHEMBL568695 | — | — | 1 | 7.75 |
| CHEMBL568242 | — | — | 1 | 7.72 |
| CHEMBL565983 | — | — | 1 | 7.70 |
| CHEMBL568444 | — | — | 1 | 7.66 |
| CHEMBL568470 | — | — | 1 | 7.66 |
| CHEMBL572184 | — | — | 1 | 7.66 |
| CHEMBL584678 | — | — | 1 | 7.66 |
| CHEMBL576658 | — | — | 1 | 7.64 |
| CHEMBL578588 | — | — | 1 | 7.62 |
| CHEMBL567375 | — | — | 1 | 7.62 |
| CHEMBL567376 | — | — | 1 | 7.60 |
| CHEMBL565362 | — | — | 1 | 7.58 |
| CHEMBL568472 | — | — | 1 | 7.58 |
| CHEMBL577694 | — | — | 1 | 7.58 |
| CHEMBL578968 | — | — | 1 | 7.58 |
| CHEMBL567169 | — | — | 1 | 7.58 |
| CHEMBL578594 | — | — | 1 | 7.57 |
| CHEMBL579258 | — | — | 1 | 7.57 |
| CHEMBL583004 | — | — | 1 | 7.55 |
| CHEMBL568243 | — | — | 1 | 7.55 |
| CHEMBL565360 | — | — | 1 | 7.55 |
| CHEMBL584813 | — | — | 1 | 7.54 |
| CHEMBL576457 | — | — | 1 | 7.48 |
| CHEMBL565361 | — | — | 1 | 7.47 |
| CHEMBL579199 | — | — | 1 | 7.44 |
| CHEMBL578578 | — | — | 1 | 7.41 |
| CHEMBL578579 | — | — | 1 | 7.41 |
| CHEMBL585191 | — | — | 1 | 7.40 |
| CHEMBL584886 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL583442 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL568695 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL568242 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL565983 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL568444 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL568470 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL572184 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL584678 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL576658 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL578588 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL567375 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL567376 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL567169 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL578968 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL577694 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL565362 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL568472 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL578594 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL579258 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL565360 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL568243 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL583004 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL584813 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL576457 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL565361 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL579199 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL578578 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL578579 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL585191 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL584886 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL577042 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL578547 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL568471 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL567374 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL565949 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL579016 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL567582 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL579200 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL568456 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL568438 | — | EC50 | = | 118.0 | nM | 6.93 |
| CHEMBL577470 | — | EC50 | = | 814.0 | nM | 6.09 |