Assay Detail
Binding
CHEMBL1048541
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Inhibition of HIV1 protease expressed in Escherichia coli by fluorometric assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
HIV-1 protease inhibitors with a transition-state mimic comprising a tertiary alcohol: improved antiviral activity in cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 8.40 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 9.70 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 9.52 |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 9.30 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 9.10 |
| CHEMBL583069 | — | — | 1 | 9.00 |
| CHEMBL1323 | DARUNAVIR | 4.0 | 1 | 8.96 |
| CHEMBL583568 | — | — | 1 | 8.96 |
| CHEMBL583371 | — | — | 1 | 8.92 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 8.85 |
| CHEMBL583370 | — | — | 1 | 8.77 |
| CHEMBL574755 | — | — | 1 | 8.77 |
| CHEMBL574797 | — | — | 1 | 8.77 |
| CHEMBL574733 | — | — | 1 | 8.74 |
| CHEMBL583070 | — | — | 1 | 8.70 |
| CHEMBL583565 | — | — | 1 | 8.64 |
| CHEMBL583372 | — | — | 1 | 8.64 |
| CHEMBL270135 | — | — | 1 | 8.55 |
| CHEMBL583564 | — | — | 1 | 8.55 |
| CHEMBL574743 | — | — | 1 | 8.54 |
| CHEMBL574795 | — | — | 1 | 8.54 |
| CHEMBL574751 | — | — | 1 | 8.49 |
| CHEMBL206467 | — | — | 1 | 8.30 |
| CHEMBL574796 | — | — | 1 | 8.10 |
| CHEMBL583566 | — | — | 1 | 8.09 |
| CHEMBL583563 | — | — | 1 | 7.96 |
| CHEMBL583369 | — | — | 1 | 7.92 |
| CHEMBL574798 | — | — | 1 | 5.91 |
| CHEMBL574710 | — | — | 1 | 5.66 |
| CHEMBL583567 | — | — | 1 | 5.56 |
| CHEMBL197500 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL5483011 | INDINAVIR | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL1163 | ATAZANAVIR | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL163 | RITONAVIR | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL583069 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1323 | DARUNAVIR | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL583568 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL583371 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL729 | LOPINAVIR | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL583370 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL574755 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL574797 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL574733 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL583070 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL583372 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL583565 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL270135 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL583564 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL574743 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL574795 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL574751 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL206467 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL574796 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL583566 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL583563 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL583369 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL574798 | — | Ki | = | 1240.0 | nM | 5.91 |
| CHEMBL574710 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL583567 | — | Ki | = | 2755.0 | nM | 5.56 |
| CHEMBL197500 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL198645 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL436755 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL573027 | — | Ki | > | 5000.0 | nM | - |