Assay Detail
Binding
CHEMBL1048592
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Inhibition of soybean 5-lipoxygenase by UV-absorbance based enzyme assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Glycine max |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.19 | 4.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 4.40 |
| CHEMBL596483 | 4,4',6-TRIMETHOXY-AURONE | — | 1 | 4.30 |
| CHEMBL476598 | — | — | 1 | 4.28 |
| CHEMBL610055 | — | — | 1 | 4.28 |
| CHEMBL241861 | — | — | 1 | 4.25 |
| CHEMBL389328 | — | — | 1 | 4.17 |
| CHEMBL611941 | 4'-METHOXY-AURONE | — | 1 | 4.16 |
| CHEMBL572323 | — | — | 1 | 4.09 |
| CHEMBL594854 | — | — | 1 | 4.00 |
| CHEMBL609307 | — | — | 1 | 4.00 |
| CHEMBL145 | CAFFEIC ACID | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL596483 | 4,4',6-TRIMETHOXY-AURONE | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL476598 | — | IC50 | = | 52500.0 | nM | 4.28 |
| CHEMBL610055 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL241861 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL389328 | — | IC50 | = | 67500.0 | nM | 4.17 |
| CHEMBL611941 | 4'-METHOXY-AURONE | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL572323 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL594854 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL609307 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL145 | CAFFEIC ACID | IC50 | = | 600000.0 | nM | - |