Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1048600

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist activity at human recombinant LXRbeta expressed in CHO cells assessed as effect on secreted alkaline phosphatase by LAFbeta assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Oxysterols receptor LXR-beta (CHEMBL4093)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

4-(3-aryloxyaryl)quinoline alcohols are liver X receptor agonists.
Bernotas RC, Kaufman DH, Singhaus RR, Ullrich J, Unwalla R, Quinet E, Nambi P, Wilhelmsson A, Goos-Nilsson A, Wrobel J.
Bioorg Med Chem (2009) 17 : 8086 -8092
PubMed 19853462 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 17 6.42 7.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL62136 T091317 1 7.80
CHEMBL595124 1 7.51
CHEMBL214719 1 7.15
CHEMBL606157 1 6.97
CHEMBL603743 1 6.68
CHEMBL595118 1 6.63
CHEMBL592985 1 6.39
CHEMBL596233 1 6.21
CHEMBL593960 1 6.19
CHEMBL471608 1 6.05
CHEMBL596047 1 6.03
CHEMBL596262 1 6.00
CHEMBL604479 1 5.99
CHEMBL595125 1 5.86
CHEMBL541472 1 5.74
CHEMBL594884 1 5.47
CHEMBL595119 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL62136 T091317 EC50 = 16.0 nM 7.80
CHEMBL595124 EC50 = 31.0 nM 7.51
CHEMBL214719 EC50 = 71.0 nM 7.15
CHEMBL606157 EC50 = 108.0 nM 6.97
CHEMBL603743 EC50 = 210.0 nM 6.68
CHEMBL595118 EC50 = 233.0 nM 6.63
CHEMBL592985 EC50 = 406.0 nM 6.39
CHEMBL596233 EC50 = 612.0 nM 6.21
CHEMBL593960 EC50 = 646.0 nM 6.19
CHEMBL471608 EC50 = 895.0 nM 6.05
CHEMBL596047 EC50 = 938.0 nM 6.03
CHEMBL596262 EC50 = 1010.0 nM 6.00
CHEMBL604479 EC50 = 1030.0 nM 5.99
CHEMBL595125 EC50 = 1370.0 nM 5.86
CHEMBL541472 EC50 = 1810.0 nM 5.74
CHEMBL594884 EC50 = 3400.0 nM 5.47
CHEMBL595119 EC50 - -