Assay Detail
Binding
CHEMBL1048658
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to adrenergic alpha1A receptor by radioligand displacement assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.99 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL605405 | — | — | 1 | 8.85 |
| CHEMBL605081 | — | — | 1 | 8.15 |
| CHEMBL592752 | MARITUPIRDINE | 2.0 | 1 | 7.72 |
| CHEMBL589390 | LATREPIRDINE | 3.0 | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL605405 | — | Ki | = | 1.413 | nM | 8.85 |
| CHEMBL605081 | — | Ki | = | 7.079 | nM | 8.15 |
| CHEMBL592752 | MARITUPIRDINE | Ki | = | 19.05 | nM | 7.72 |
| CHEMBL589390 | LATREPIRDINE | Ki | = | 60.26 | nM | 7.22 |