Assay Detail
Binding
CHEMBL1048661
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Lysergic acid from human recombinant 5HT6 receptor expressed in human HeLa cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.50 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL605405 | — | — | 1 | 9.21 |
| CHEMBL592752 | MARITUPIRDINE | 2.0 | 1 | 8.70 |
| CHEMBL605081 | — | — | 1 | 8.62 |
| CHEMBL589390 | LATREPIRDINE | 3.0 | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL605405 | — | Ki | = | 0.6166 | nM | 9.21 |
| CHEMBL592752 | MARITUPIRDINE | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL605081 | — | Ki | = | 2.399 | nM | 8.62 |
| CHEMBL589390 | LATREPIRDINE | Ki | = | 33.88 | nM | 7.47 |