Assay Detail
Functional
CHEMBL1048713
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania amazonensis MHOM/BR/76/LTB-012 amastigotes infected in mouse macrophage by MTT assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania amazonensis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 5.07 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.00 |
| CHEMBL493445 | — | — | 1 | 6.22 |
| CHEMBL589848 | — | — | 1 | 5.96 |
| CHEMBL492414 | — | — | 1 | 5.96 |
| CHEMBL601471 | — | — | 1 | 5.89 |
| CHEMBL521680 | — | — | 1 | 5.39 |
| CHEMBL589850 | — | — | 1 | 5.34 |
| CHEMBL524176 | — | — | 1 | 5.26 |
| CHEMBL594360 | — | — | 1 | 5.21 |
| CHEMBL601679 | — | — | 1 | 5.19 |
| CHEMBL523881 | — | — | 1 | 5.18 |
| CHEMBL593899 | — | — | 1 | 5.13 |
| CHEMBL494900 | — | — | 1 | 5.10 |
| CHEMBL493861 | — | — | 1 | 5.09 |
| CHEMBL495103 | — | — | 1 | 5.08 |
| CHEMBL589609 | — | — | 1 | 5.07 |
| CHEMBL494075 | — | — | 1 | 5.06 |
| CHEMBL523014 | — | — | 1 | 5.03 |
| CHEMBL600446 | — | — | 1 | 5.03 |
| CHEMBL493470 | — | — | 1 | 5.02 |
| CHEMBL494899 | — | — | 1 | 5.02 |
| CHEMBL601294 | — | — | 1 | 5.01 |
| CHEMBL494264 | — | — | 1 | 5.00 |
| CHEMBL601680 | — | — | 1 | 4.97 |
| CHEMBL609576 | — | — | 1 | 4.95 |
| CHEMBL589610 | — | — | 1 | 4.93 |
| CHEMBL589611 | — | — | 1 | 4.93 |
| CHEMBL589851 | — | — | 1 | 4.93 |
| CHEMBL576316 | — | — | 1 | 4.92 |
| CHEMBL589608 | — | — | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL493445 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL492414 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL589848 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL601471 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL521680 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL589850 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL524176 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL594360 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL601679 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL523881 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL593899 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL494900 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL493861 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL495103 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL589609 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL494075 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL523014 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL600446 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL493470 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL494899 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL601294 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL494264 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL601680 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL609576 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL589610 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL589611 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL589851 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL576316 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL589608 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL593898 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL507998 | HELICHRYSETIN | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL243829 | FLAVOKAWAIN A | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL589849 | — | IC50 | = | 52600.0 | nM | 4.28 |
| CHEMBL494090 | — | IC50 | = | 75200.0 | nM | 4.12 |
| CHEMBL494074 | — | IC50 | = | 79800.0 | nM | 4.10 |
| CHEMBL522684 | — | IC50 | = | 85200.0 | nM | 4.07 |
| CHEMBL492415 | — | IC50 | = | 94300.0 | nM | 4.03 |
| CHEMBL493469 | — | IC50 | = | 127600.0 | nM | - |
| CHEMBL522017 | — | IC50 | = | 134500.0 | nM | - |
| CHEMBL495104 | — | IC50 | > | 180000.0 | nM | - |
| CHEMBL494281 | — | IC50 | = | 107200.0 | nM | - |
| CHEMBL492416 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL407578 | — | IC50 | > | 300000.0 | nM | - |