Assay Detail
Functional
CHEMBL1048714
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania braziliensis MHOM/PE/PER006 promastigotes infected in mouse macrophage by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania braziliensis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.26 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.00 |
| CHEMBL492414 | — | — | 1 | 5.85 |
| CHEMBL601471 | — | — | 1 | 5.28 |
| CHEMBL494264 | — | — | 1 | 5.12 |
| CHEMBL521680 | — | — | 1 | 5.07 |
| CHEMBL594360 | — | — | 1 | 4.88 |
| CHEMBL589848 | — | — | 1 | 4.84 |
| CHEMBL589851 | — | — | 1 | 4.76 |
| CHEMBL589850 | — | — | 1 | 4.52 |
| CHEMBL601679 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL492414 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL601471 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL494264 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL521680 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL594360 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL589848 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL589851 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL589850 | — | IC50 | = | 30400.0 | nM | 4.52 |
| CHEMBL601679 | — | IC50 | = | 237000.0 | nM | - |