Assay Detail
Functional
CHEMBL1048715
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Antileishmanial activity against Leishmania peruviana MHOM/PE/LCA08 promastigotes infected in mouse macrophage by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania peruviana |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro and in vivo anti-Leishmania activity of polysubstituted synthetic chalcones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.06 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 7.00 |
| CHEMBL492414 | — | — | 1 | 5.40 |
| CHEMBL594360 | — | — | 1 | 4.71 |
| CHEMBL521680 | — | — | 1 | 4.71 |
| CHEMBL494264 | — | — | 1 | 4.64 |
| CHEMBL589850 | — | — | 1 | 4.47 |
| CHEMBL589851 | — | — | 1 | 4.46 |
| CHEMBL601471 | — | — | 1 | - |
| CHEMBL589848 | — | — | 1 | - |
| CHEMBL601679 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL492414 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL594360 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL521680 | — | IC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL494264 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL589850 | — | IC50 | = | 34200.0 | nM | 4.47 |
| CHEMBL589851 | — | IC50 | = | 34800.0 | nM | 4.46 |
| CHEMBL601471 | — | IC50 | = | 110800.0 | nM | - |
| CHEMBL589848 | — | IC50 | - | — | - | |
| CHEMBL601679 | — | IC50 | = | 290200.0 | nM | - |