Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1048735

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against mouse L1210 cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Autocuration

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

Design, synthesis and bioevaluation of novel maleamic amino acid ester conjugates of 3,5-bisarylmethylene-4-piperidones as cytostatic agents.
Youssef D, Potter E, Jha M, De Clercq E, Balzarini J, Stables JP, Jha A.
Bioorg Med Chem Lett (2009) 19 : 6364 -6367
PubMed 19819135 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.83 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL577326 1 6.70
CHEMBL570628 1 6.62
CHEMBL158037 1 6.38
CHEMBL577324 1 6.36
CHEMBL577323 1 6.24
CHEMBL577325 1 6.24
CHEMBL577322 1 6.22
CHEMBL577533 1 6.21
CHEMBL571870 1 6.08
CHEMBL852 MELPHALAN 4.0 1 5.67
CHEMBL577109 1 5.34
CHEMBL570299 1 5.33
CHEMBL585540 1 5.21
CHEMBL154716 1 5.10
CHEMBL156016 1 5.06
CHEMBL348877 1 4.49

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL577326 IC50 = 200.0 nM 6.70
CHEMBL570628 IC50 = 240.0 nM 6.62
CHEMBL158037 IC50 = 420.0 nM 6.38
CHEMBL577324 IC50 = 440.0 nM 6.36
CHEMBL577323 IC50 = 580.0 nM 6.24
CHEMBL577325 IC50 = 580.0 nM 6.24
CHEMBL577322 IC50 = 600.0 nM 6.22
CHEMBL577533 IC50 = 620.0 nM 6.21
CHEMBL571870 IC50 = 840.0 nM 6.08
CHEMBL852 MELPHALAN IC50 = 2130.0 nM 5.67
CHEMBL577109 IC50 = 4600.0 nM 5.34
CHEMBL570299 IC50 = 4700.0 nM 5.33
CHEMBL585540 IC50 = 6100.0 nM 5.21
CHEMBL154716 IC50 = 7960.0 nM 5.10
CHEMBL156016 IC50 = 8690.0 nM 5.06
CHEMBL348877 IC50 = 32090.0 nM 4.49