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Assay Detail

CHEMBL1048798

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Binding
Inhibition of Beta-lactamase AmpC by quantitative high throughput screening
ChEMBL ↗
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease.
Jadhav A, Ferreira RS, Klumpp C, Mott BT, Austin CP, Inglese J, Thomas CJ, Maloney DJ, Shoichet BK, Simeonov A.
J Med Chem (2010) 53 : 37 -51
PubMed 19908840 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 42 5.12 5.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL586058 — — 1 5.70
CHEMBL12998 L-755507 — 1 5.52
CHEMBL566690 — — 1 5.52
CHEMBL565812 — — 1 5.40
CHEMBL566707 — — 1 5.40
CHEMBL570844 — — 1 5.40
CHEMBL568419 — — 1 5.40
CHEMBL568420 — — 1 5.40
CHEMBL567735 — — 1 5.40
CHEMBL81 RALOXIFENE 4.0 1 5.30
CHEMBL566932 — — 1 5.22
CHEMBL577938 — — 1 5.22
CHEMBL566064 — — 1 5.10
CHEMBL577758 — — 1 5.10
CHEMBL577546 — — 1 5.10
CHEMBL576039 — — 1 5.00
CHEMBL578136 — — 1 5.00
CHEMBL39878 — — 1 5.00
CHEMBL571296 — — 1 5.00
CHEMBL567323 — — 1 5.00
CHEMBL566933 — — 1 4.89
CHEMBL566068 — — 1 4.89
CHEMBL31574 FISETIN 2.0 1 4.89
CHEMBL567531 — — 1 4.89
CHEMBL567529 — — 1 4.89
CHEMBL567337 — — 1 4.89
CHEMBL567335 — — 1 4.89
CHEMBL566706 — — 1 4.89
CHEMBL567130 — — 1 4.89
CHEMBL299879 — — 1 4.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL586058 — IC50 = 2000.0 nM 5.70
CHEMBL12998 L-755507 IC50 = 3000.0 nM 5.52
CHEMBL566690 — IC50 = 3000.0 nM 5.52
CHEMBL565812 — IC50 = 4000.0 nM 5.40
CHEMBL566707 — IC50 = 4000.0 nM 5.40
CHEMBL570844 — IC50 = 4000.0 nM 5.40
CHEMBL568419 — IC50 = 4000.0 nM 5.40
CHEMBL568420 — IC50 = 4000.0 nM 5.40
CHEMBL567735 — IC50 = 4000.0 nM 5.40
CHEMBL81 RALOXIFENE IC50 = 5000.0 nM 5.30
CHEMBL566932 — IC50 = 6000.0 nM 5.22
CHEMBL577938 — IC50 = 6000.0 nM 5.22
CHEMBL577758 — IC50 = 8000.0 nM 5.10
CHEMBL577546 — IC50 = 8000.0 nM 5.10
CHEMBL566064 — IC50 = 8000.0 nM 5.10
CHEMBL576039 — IC50 = 10000.0 nM 5.00
CHEMBL567323 — IC50 = 10000.0 nM 5.00
CHEMBL571296 — IC50 = 10000.0 nM 5.00
CHEMBL39878 — IC50 = 10000.0 nM 5.00
CHEMBL578136 — IC50 = 10000.0 nM 5.00
CHEMBL566068 — IC50 = 13000.0 nM 4.89
CHEMBL578585 — IC50 = 13000.0 nM 4.89
CHEMBL299879 — IC50 = 13000.0 nM 4.89
CHEMBL567130 — IC50 = 13000.0 nM 4.89
CHEMBL566706 — IC50 = 13000.0 nM 4.89
CHEMBL567335 — IC50 = 13000.0 nM 4.89
CHEMBL567337 — IC50 = 13000.0 nM 4.89
CHEMBL567529 — IC50 = 13000.0 nM 4.89
CHEMBL567531 — IC50 = 13000.0 nM 4.89
CHEMBL31574 FISETIN IC50 = 13000.0 nM 4.89
CHEMBL566933 — IC50 = 13000.0 nM 4.89
CHEMBL567356 — IC50 = 16000.0 nM 4.80
CHEMBL577752 — IC50 - — -
CHEMBL566920 — IC50 - — -
CHEMBL566931 — IC50 - — -
CHEMBL571065 — IC50 - — -
CHEMBL579075 — IC50 - — -
CHEMBL567959 — IC50 - — -
CHEMBL567132 — IC50 - — -
CHEMBL585685 — IC50 - — -
CHEMBL567145 — IC50 - — -
CHEMBL565862 — IC50 - — -