Assay Detail
Binding
CHEMBL1048801
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Inhibition of Trypanosoma cruzi cruzain after 15 mins
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.71 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567341 | — | — | 1 | 8.00 |
| CHEMBL578159 | — | — | 1 | 7.89 |
| CHEMBL577121 | — | — | 1 | 7.75 |
| CHEMBL567142 | — | — | 1 | 7.75 |
| CHEMBL567340 | — | — | 1 | 7.60 |
| CHEMBL578162 | — | — | 1 | 7.40 |
| CHEMBL567786 | — | — | 1 | 7.30 |
| CHEMBL568171 | — | — | 1 | 7.20 |
| CHEMBL567783 | — | — | 1 | 7.20 |
| CHEMBL566904 | — | — | 1 | 7.20 |
| CHEMBL566905 | — | — | 1 | 7.15 |
| CHEMBL567784 | — | — | 1 | 7.10 |
| CHEMBL567785 | — | — | 1 | 7.10 |
| CHEMBL566924 | — | — | 1 | 7.00 |
| CHEMBL576648 | — | — | 1 | 6.90 |
| CHEMBL567147 | — | — | 1 | 6.90 |
| CHEMBL567134 | — | — | 1 | 6.60 |
| CHEMBL585873 | — | — | 1 | 6.50 |
| CHEMBL568172 | — | — | 1 | 6.40 |
| CHEMBL566069 | — | — | 1 | 6.15 |
| CHEMBL567161 | — | — | 1 | 6.15 |
| CHEMBL576847 | — | — | 1 | 6.10 |
| CHEMBL567137 | — | — | 1 | 6.05 |
| CHEMBL566067 | — | — | 1 | 6.05 |
| CHEMBL565866 | — | — | 1 | 6.05 |
| CHEMBL567135 | — | — | 1 | 6.05 |
| CHEMBL566691 | — | — | 1 | 6.05 |
| CHEMBL566903 | — | — | 1 | 5.95 |
| CHEMBL567354 | — | — | 1 | 5.90 |
| CHEMBL578161 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567341 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL578159 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL577121 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL567142 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL567340 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL578162 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL567786 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL568171 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL567783 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL566904 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL566905 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL567784 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL567785 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL566924 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL567147 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL576648 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL567134 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL585873 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL568172 | — | IC50 | = | 398.0 | nM | 6.40 |
| CHEMBL566069 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL567161 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL576847 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL567137 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL566067 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL565866 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL567135 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL566691 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL566903 | — | IC50 | = | 1122.0 | nM | 5.95 |
| CHEMBL567354 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL578161 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL567769 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL566273 | — | IC50 | = | 2239.0 | nM | 5.65 |
| CHEMBL579273 | — | IC50 | - | — | - |