Assay Detail
Binding
CHEMBL1048802
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Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysis
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.21 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567341 | — | — | 1 | 9.70 |
| CHEMBL578162 | — | — | 1 | 9.52 |
| CHEMBL577121 | — | — | 1 | 9.40 |
| CHEMBL567783 | — | — | 1 | 9.00 |
| CHEMBL567340 | — | — | 1 | 9.00 |
| CHEMBL567785 | — | — | 1 | 8.70 |
| CHEMBL566924 | — | — | 1 | 8.70 |
| CHEMBL568171 | — | — | 1 | 8.40 |
| CHEMBL567784 | — | — | 1 | 8.00 |
| CHEMBL568172 | — | — | 1 | 8.00 |
| CHEMBL567147 | — | — | 1 | 7.52 |
| CHEMBL576648 | — | — | 1 | 7.52 |
| CHEMBL579273 | — | — | 1 | 7.40 |
| CHEMBL566273 | — | — | 1 | 7.30 |
| CHEMBL566903 | — | — | 1 | 7.22 |
| CHEMBL577764 | — | — | 1 | 7.16 |
| CHEMBL571295 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567341 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL578162 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL577121 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL567783 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL567340 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL567785 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL566924 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL568171 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL567784 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL568172 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL567147 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL576648 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL579273 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL566273 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL566903 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL577764 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL571295 | — | IC50 | = | 90.0 | nM | 7.05 |